@article{17373,
  keywords = {Adolescent, Adult, Aged, Biological Assay, Humans, Leprostatic Agents, leprosy, Middle Aged, Mycobacterium bovis, Nerve Tissue, Oxidation-Reduction, Palmitic Acids, Rifampin, Tibial Nerve},
  author = {Guebre-Xabier M and Shannon E J and Kazen R and Kebret Z and Frommel D},
  title = {Early detection of rifampin in human nerve tissue after an oral dose of 600 milligrams.},
  abstract = {<p>Rifampin in picogram quantities inhibited the ability of Mycobacterium bovis 44 BCG P3 to release 14CO2 from the oxidation of [14C]palmitic acid. By using these mycobacteria in a bioassay, samples of serum and posterior tibial nerve were assayed for inhibitory concentrations of rifampin. Within 8 to 12 h after ingestion of 600 mg of rifampin, the drug was detected in eight patients in concentrations ranging from 0.52 to 4.1 micrograms/ml in serum and in concentrations ranging from 0.6 to 6.3 ng/mg in posterior tibial nerve fiber tissue.</p>},
  year = {1995},
  journal = {Antimicrobial agents and chemotherapy},
  volume = {39},
  pages = {1866-70},
  month = {1995 Aug},
  issn = {0066-4804},
  doi = {10.1128/aac.39.8.1866},
  language = {eng},
}