@article{1723,
  keywords = {Brazil, Cohort Studies, Follow-Up Studies, Humans, Incidence, leprosy, Logistic Models, Multivariate Analysis, Residence Characteristics, Risk Factors, Time Factors},
  author = {Matos H J and Duppre N and Alvim M F and MachadoVieira L M and Sarno E N and Struchiner C J},
  title = {[Leprosy epidemiology in a cohort of household contacts in Rio de Janeiro (1987-1991)].},
  abstract = {<p>This study aimed to identify factors influencing the development of leprosy (Hansen's disease) in household contacts. A dynamic cohort was analyzed from 1987 to 1991 at the Hansen's Disease Department of the Oswaldo Cruz Foundation in Rio de Janeiro. The incidence rate was 0.01694 person-years of follow-up. Nevertheless, for subjects at the end of the first year of follow-up the incidence rate was 0.06385 (end of second year, 0.03299; end of third year, 0.02370; end of fourth year, 0.018622; and end of observation period, 0.01694). A stepwise multivariate logistic regression model was proposed to study the risk of developing leprosy, including co-prevalent cases, totaling 758 contacts. In the final model, the risk was associated with a negative Mitsuda skin test (OR = 3.093; CI 95% = 1.735-5.514), prior BCG vaccination (OR = 0.3802; CI 95% = 0.2151-0.66719), and multibacillary primary clinical form (OR = 2.547; CI 95% = 1.249-5.192). The results showed that both multibacillary leprosy and specific immune status are significant indicators for developing the disease in a cohort of household contacts.</p>},
  year = {1999},
  journal = {Cadernos de saude publica},
  volume = {15},
  pages = {533-42},
  month = {1999 Jul-Sep},
  issn = {0102-311X},
  url = {http://www.scielo.br/pdf/csp/v15n3/0492.pdf},
  doi = {10.1590/s0102-311x1999000300010},
  language = {por},
}