@article{16749,
  keywords = {Cell Membrane, Cell Wall, Clofazimine, Dapsone, Humans, leprosy, Microscopy, Electron, Mycobacterium leprae, Organoids, Ribosomes, Rifampin, Skin},
  author = {Silva M T and Macedo P M and Costa M H and Gonçalves H and Torgal J and David H L},
  title = {Ultrastructural alterations of mycobacterium leprae in skin biopsies of untreated and treated lepromatous patients.},
  abstract = {<p>1. -- Mycobacterium leprae cells under a process of progressive disaggregation are present in the skin of both treated and untreated patients. 2. -- The ultrastructural alterations observed during the degenerative process seem to be qualitatively similar in treated and untreated patients. 3. -- The proportion of altered M. leprae cells increases during the treatment, mainly with rifampicin and rifampicin + clofazimine + diaminodiphenyl sulfone. 4. -- The cell wall of M. leprae is the last bacterial structure to disappear during the degenerative process.</p>},
  year = {1982},
  journal = {Annales de microbiologie},
  volume = {133},
  pages = {75-92},
  month = {1982 Jul-Aug},
  issn = {0300-5410},
  language = {eng},
}