@article{1674,
  keywords = {Animals, Antigens, Bacterial, Bacterial Vaccines, Interferon-gamma, leprosy, Mice, Mice, Inbred BALB C, Mice, Nude, Mycobacterium leprae, Spleen},
  author = {Naito M and Matsuoka M and Ohara N and Nomaguchi H and Yamada T},
  title = {The antigen 85 complex vaccine against experimental Mycobacterium leprae infection in mice.},
  abstract = {<p>The proteins in culture filtrate derived from Bacillus Calmette-Guérin (BCG) were examined for protection against infection by Mycobacterium leprae. Immunization with the major secreted proteins, antigen 85 complex (Ag 85) A, B and C, induced effective protective immunity against multiplication of M. leprae in the foot pads of mice. The most effective protection was observed when mice were immunized with Ag 85A. A single immunization with Ag 85 could induce antigen-specific interferon gamma (IFNgamma) synthesis and more effective protection than live BCG vaccine. This study demonstrates that Ag 85 is an important immunoprotective molecule against leprosy infection.</p>},
  year = {1999},
  journal = {Vaccine},
  volume = {18},
  pages = {795-8},
  month = {1999 Dec 10},
  issn = {0264-410X},
  doi = {10.1016/s0264-410x(99)00327-8},
  language = {eng},
}