@article{1671,
  keywords = {Adolescent, Adult, Aged, Antigens, Bacterial, Chromatography, Thin Layer, Enzyme-Linked Immunosorbent Assay, Female, Glycolipids, Humans, Immunoglobulin G, Immunoglobulin M, leprosy, Male, Middle Aged, Mycobacterium leprae, Tuberculosis},
  author = {Rojas-Espinosa O and Luna-Herrera J and Arce-Paredes P},
  title = {Recognition of phenolic glycolipid-I (Mycobacterium leprae) and sulfolipid-I (M. tuberculosis) by serum from Mexican patients with leprosy or tuberculosis.},
  abstract = {<p><b>SETTING: </b>Differential diagnosis of leprosy and tuberculosis in regions where both illnesses are endemic is a prerequisite for proper identification and treatment.</p><p><b>OBJECTIVE: </b>To evaluate the recognition of phenolic glycolipid-I (PGL-I) of Mycobacterium leprae and sulfolipid-I (SL-I) of M. tuberculosis by serum from patients with leprosy (LL) or pulmonary tuberculosis (PTB).</p><p><b>DESIGN: </b>Purified PGL-I and SL-I were used as antigens in an ELISA test set up to assess recognition of these lipids by serum from 43 LL patients, 44 PTB patients and 38 healthy individuals.</p><p><b>RESULTS: </b>Leprosy patients gave higher IgM than IgG responses to PGL-I and had comparable IgM and IgG responses to SL-I. A similar situation was observed with PTB serum. Some healthy individuals were found to contain significant levels of antibodies to both lipids.</p><p><b>CONCLUSION: </b>There is no specific recognition of either of the two lipid antigens tested by serum from both leprosy and tuberculosis patients; this rules out the possibility of using PGL-I and SL-I as tools for the differential diagnosis of these two mycobacterial diseases.</p>},
  year = {1999},
  journal = {The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease},
  volume = {3},
  pages = {1106-12},
  month = {1999 Dec},
  issn = {1027-3719},
  language = {eng},
}