@article{16696,
  keywords = {Female, Gene Frequency, Genetic Markers, Haploidy, Histocompatibility Antigens Class II, Humans, leprosy, Male, Meiosis, Mycobacterium leprae, Phenotype},
  author = {Vries R R and Mehra N K and Vaidya M C and Gupte M D and Meera Khan P and Rood J J},
  title = {HLA-linked control of susceptibility to tuberculoid leprosy and association with HLA-DR types.},
  abstract = {<p>In an attempt to confirm an HLA-linked effect on the course of Mycobacterium leprae infection observed in families from Surinam (South America), we conducted a similar family study in an endemic area in India. We observed a significant (P less than .05) excess of identical HLA-GLO haplotypes only from healthy parents among siblings affected with tuberculoid leprosy. Compared with healthy controls, unrelated patients with tuberculoid leprosy (n = 15) showed a significant heterogeneity at the HLA-DR locus (P less than .05). This heterogeneity was caused by an increased frequency of HLA-DRw2 (.93 versus .53, P less than .05), particularly of DRw2 homozygotes (.53 versus .11, P less than .005), and a decreased frequency of HLA-DRw6 (.07 versus .58, P less than .005). We observed a significant (P = .03) preferential segregation of DRw2 from DRw2 heterozygous parents not affected with tuberculoid leprosy to children with the tuberculoid type of the disease. These data confirm an HLA-linked control of susceptibility to tuberculoid leprosy only, and suggest a recessive inheritance of this trait for which HLA-Drw2 appears to be a genetic marker.</p>},
  year = {1980},
  journal = {Tissue antigens},
  volume = {16},
  pages = {294-304},
  month = {1980 Oct},
  issn = {0001-2815},
  doi = {10.1111/j.1399-0039.1980.tb00309.x},
  language = {eng},
}