@article{16603,
  keywords = {Adult, B-Lymphocytes, Dose-Response Relationship, Immunologic, Fetal Blood, Gastrointestinal Neoplasms, Humans, Immunity, Cellular, Infant, Newborn, leprosy, Rosette Formation, T-Lymphocytes, Thymus Extracts},
  author = {Shoham J and Cohen M and Chandali Y and Avni A},
  title = {Thymic hormonal activity on human peripheral blood lymphocytes, in vitro. I. Reciprocal effect on T and B rosette formation.},
  abstract = {<p>One hour incubation with the thymic extract TP-1 induced reciprocal effect on B and T rosette formation in lymphocytes of human peripheral blood. The percentage of mouse erythrocyte rosette-forming cells among lymphocytes of chronic lymphatic leukaemia was decreased by TP-1 from 54.5% to 27.1% (P < 0.001). No such effect was observed in healthy adult or cord blood lymphocytes. On the other hand, the percentage of sheep erythrocyte rosette forming cells increased significantly after TP-1 treatment, but only under conditions of active rosette formation and not in the total rosette assay. This increase was highly significant in three conditions with relative deficiency of cell-mediated immunity: newborns (17.1 to 28.3%), cancer patients (24.5 to 31.7%) and patients with lepromatous leprosy (19.8 to 31.8%). Only a small increase was noticed in healthy adults. A similarly prepared spleen extract was not active in either B or T rosette assays.</p>},
  year = {1980},
  journal = {Immunology},
  volume = {41},
  pages = {353-9},
  month = {1980 Oct},
  issn = {0019-2805},
  language = {eng},
}