@article{16586,
  keywords = {Antibodies, Antinuclear, Antigen-Antibody Complex, Autoantibodies, Complement System Proteins, Humans, Immunoglobulins, leprosy, Platelet Aggregation, Rheumatoid Factor, Skin},
  author = {Sehgal S and Kumar B},
  title = {Circulating and tissue immune complexes in leprosy.},
  abstract = {<p>Various immunological studies were conducted in lepromatous leprosy patients. There was a polyclonal rise of all the three major immunoglobulins. Serum IgD levels remained unaltered. Positive latex agglutination reactions (RA) and parietal cell antibodies were distinctly more frequent in patients. Eighty-five percent of patients showed a strongly positive complement deviation test, and the mean platelet aggregation titer was 1 in 81 in the patients compared to 1 in 3 in the controls, thus indicating the presence of circulating immune complexes in a large percentage of cases. Immunoglobulins and complement were observed in the dermal capillaries and small arterioles, but not in larger vessels, in 6 of 17 cases. Only one case showed staining of the dermoepidermal junction. Antinuclear antibodies (ANA) were detected in a single patient, and this patient also showed ANA in vivo.</p>
},
  year = {1981},
  journal = {International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association},
  volume = {49},
  pages = {294-301},
  month = {1981 Sep},
  issn = {0148-916X},
  url = {http://ila.ilsl.br/pdfs/v49n3a02.pdf},
  language = {eng},
}