@article{16530,
  keywords = {Acid Phosphatase, Alkaline Phosphatase, Animals, Ascitic Fluid, Cathepsins, Deoxyribonucleases, Female, Glucuronidase, leprosy, Lipase, Lysosomes, Macrophages, Male, Mice, Mice, Inbred Strains, Phagocytosis},
  author = {Rojas-Espinosa O and Rodríguez-Paez L and González-Cruz O and Estrada-Parra S},
  title = {Phagocytosis in leprosy. 5. The effect of the infection with Mycobacterium lepraemurium on the level of diverse hydrolytic lysosomal enzymes of murine peritoneal macrophages.},
  abstract = {<p>The effect of the infection with M. lepraemurium on the activity of several lysosomal enzymes of mouse peritoneal cells was studied. The enzymes studies were acid- and alkaline-phosphatases, acid (cathepsin D-type) proteinase, beta-glucuronidase, deoxyribonuclease, a nonspecific lipase, and lysozyme. Enzyme determinations were carried out four months and six months after the infection with 15.5 X 10(7) bacilli per mouse. Clear differences between M. lepraemurium-infected and normal animals were observed at four months of infection, with all of the mentioned enzyme activities well above the normal values. At six months of infection, a tendency to decrease to normal values of the enzyme activities was observed. It is suggested that this biochemical activation of mouse peritoneal cells reflects the effect of the cell-mediated immune response triggered by the infection with the murine leprosy bacillus. M. lepraemurium-infected mice possess macrophages in a high state of biochemical activation; yet, they are unable to get rid of the infecting microorganism.</p>},
  year = {1982},
  journal = {International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association},
  volume = {50},
  pages = {306-15},
  month = {1982 Sep},
  issn = {0148-916X},
  language = {eng},
}