@article{1629,
  keywords = {Antibodies, Apoptosis, Calcium Signaling, Cells, Cultured, Humans, Interleukin-2, Ionomycin, leprosy, Leprosy, lepromatous, Leprosy, Tuberculoid, Leukocytes, Mononuclear, Monensin, Tumor Necrosis Factor-alpha, Zinc},
  author = {Gupta A and Sharma V K and Vohra H and Ganguly N K},
  title = {Inhibition of apoptosis by ionomycin and zinc in peripheral blood mononuclear cells (PBMC) of leprosy patients.},
  abstract = {<p>PBMC from tuberculoid (BT/TT) and lepromatous leprosy (BL/LL) leprosy patients showed spontaneous apoptosis when cultured in the absence of mitogen for 24 h, which was inhibited by anti-tumour necrosis factor-alpha (TNF-alpha) antibodies. Apoptosis was also inhibited by ionomycin and zinc, which also increased IL-2 and decreased TNF-alpha production. The increase in IL-2 production suggests a mechanism whereby dietary supplements with zinc might alter the cell-mediated immunity response in leprosy patients.</p>},
  year = {1999},
  journal = {Clinical and experimental immunology},
  volume = {117},
  pages = {56-62},
  month = {1999 Jul},
  issn = {0009-9104},
  url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1905487/pdf/cei0117-0056.pdf},
  doi = {10.1046/j.1365-2249.1999.00908.x},
  language = {eng},
}