@article{16228, keywords = {Adrenal Glands, Adult, Humans, Hydrocortisone, leprosy, Middle Aged}, author = {Balybin E S and NAZAROV K I}, title = {Hydrocortisone production in lepromatous patients with insulin load.}, abstract = {

Hydrocortisone production was studied in 36 patients with lepromatous leprosy before and after insulin load as a stress factor using a competitive radioassay. Twenty-three patients showed a so-called paradoxical type of hydrocortisone production suggestive of markedly exhausted hydrocortisone-producing function of the adrenal cortex. Reserve hydrocortisone production was depressed in most of the patients with active disease; while cured patients showed a partial restoration in reserve hydrocortisone production. Leprosy relapses seem to be among the factors affecting the reserve hydrocortisone-producing function of adrenals. The question of reassessment of the principles of steroid therapy in lepromatous patients with relapses is raised.

}, year = {1983}, journal = {International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association}, volume = {51}, pages = {18-21}, month = {1983 Mar}, issn = {0148-916X}, url = {http://ila.ilsl.br/pdfs/v51n1a03.pdf}, language = {eng}, }