@article{16225, keywords = {Erythrocytes, Glucosephosphate Dehydrogenase, Glucosephosphate Dehydrogenase Deficiency, Humans, Isoenzymes, leprosy, Phenotype}, author = {Saoji A M and Kelkar S S}, title = {Erythrocyte glucose-6-phosphate dehydrogenase isoenzyme phenotypes in leprosy.}, abstract = {

Hemolysates from 50 cases of leprosy and five controls were studied for glucose-6-phosphate dehydrogenase (G-6-PD) isoenzyme phenotypes by polyacrylamide disc gel electrophoresis using a miniaturized system. The cases were classified as lepromatous (24), borderline lepromatous (5), borderline tuberculoid (5), and tuberculoid (16) according to the Ridley-Jopling scale. All had been on treatment with dapsone for between two and 12 years. None of the cases showed deficiency of erythrocyte G-6-PD. All the cases and the controls showed the G-6-PD phenotype to be of the B+ variety. Therefore this genetic marker does not appear to be related to susceptibility to leprosy or to the clinical variety of the disease in our situation.

}, year = {1983}, journal = {International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association}, volume = {51}, pages = {41-4}, month = {1983 Mar}, issn = {0148-916X}, url = {http://ila.ilsl.br/pdfs/v51n1a07.pdf}, language = {eng}, }