@article{15967,
  keywords = {HLA Antigens, HLA-DR Antigens, Histocompatibility Antigens Class II, Humans, leprosy, Venezuela},
  author = {Ottenhoff T H and Gonzalez N M and Vries R R and Convit J and Rood J J},
  title = {Association of HLA specificity LB-E12 (MB1, DC1, MT1) with lepromatous leprosy in a Venezuelan population.},
  abstract = {<p>To investigate whether an association could be found between HLA and lepromatous leprosy a population study was performed in Tachira, Venezuela. This was done in the same endemic area in which recently both non-random parental HLA-haplotype and preferential segregation of the HLA specificity LB-E12 (MB1, DC1, MT1) was demonstrated in lepromatous leprosy patients from multicase families. In this study 32 lepromatous patients and 32 healthy controls were typed for HLA-A, -B, -C, -DR and the specificities MB and MT. The frequency of LB-E12 (MB1, DC1, MT1) showed a significant increase in lepromatous leprosy patients (p = 0.04). This is the first report concerning HLA and leprosy which confirms in the same endemic area an association observed in families on the population level.</p>},
  year = {1984},
  journal = {Tissue antigens},
  volume = {24},
  pages = {25-9},
  month = {1984 Jul},
  issn = {0001-2815},
  doi = {10.1111/j.1399-0039.1984.tb00393.x},
  language = {eng},
}