@article{15795,
  keywords = {Genes, MHC Class II, HLA-DR3 Antigen, Histocompatibility Antigens Class II, Histocompatibility Testing, Humans, leprosy, Tuberculin, Tuberculin Test},
  author = {Eden W and Vries R R and Stanford J L and Rook G A},
  title = {HLA-DR3 associated genetic control of response to multiple skin tests with new tuberculins.},
  abstract = {<p>Multiple skin testing with mycobacterial antigenic preparations reveals distinct reaction patterns, which might be relevant to the development of mycobacterial disease in man. Previous work has shown that HLA-DR associated factors correlate with the position of a leprosy patient in the immunopathological spectrum of leprosy. This study was undertaken to see whether these skin test patterns in healthy persons do show any association with HLA-DR types. Out of a group of 74 healthy Caucasoid individuals HLA-DR3 was observed to be absent from the 16 individuals who did not respond to any of the mycobacterial antigens tested. This is a striking difference from the distribution of HLA-DR3 both among the 17 individuals who responded to all mycobacterial antigens tested (P = 0.005) and the 41 individuals who responded to some but not all antigens (P = 0.015). These data show that an HLA-DR3 associated genetic factor controls, albeit indirectly, skin test responsiveness to mycobacterial antigens. It may be significant that this same HLA-DR determinant is implicated in deciding the type of disease to be developed by a leprosy patient.</p>},
  year = {1983},
  journal = {Clinical and experimental immunology},
  volume = {52},
  pages = {287-92},
  month = {1983 May},
  issn = {0009-9104},
  url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1535848/pdf/clinexpimmunol00158-0051.pdf},
  language = {eng},
}