@article{15650,
  keywords = {Bacterial Vaccines, Drug Resistance, Microbial, History, 19th Century, History, 20th Century, History, Ancient, History, Medieval, Humans, leprosy, Lymphocyte Activation, Mycobacterium leprae},
  author = {Stewart-Tull D E},
  title = {Leprosy--in pursuit of a vaccine.},
  abstract = {<p>Clinical leprosy is characterized by varying manifestations between tuberculoid and lepromatous leprosy. In the former state the patient is able to elicit a cell-mediated immune response whereas in the latter, there is usually a humoral response. An understanding of this immunological balance is crucial in the search for a vaccine which will control the disease. The development of a possible anti-Mycobacterium leprae vaccine has been advanced by the isolation of organisms from the infected tissues of the nine-banded armadillo, Dasypus novemcinctus; 125 000 doses can be prepared from one animal. In addition, recent studies on the biochemical activities of these organisms may provide the knowledge required to allow cultivation on a laboratory medium. Eventually it may be possible to produce a combined leprosy:tuberculosis vaccine for use in those parts of the world where both diseases are prevalent.</p>},
  year = {1984},
  journal = {Vaccine},
  volume = {2},
  pages = {238-48},
  month = {1984 Dec},
  issn = {0264-410X},
  doi = {10.1016/0264-410x(84)90037-9},
  language = {eng},
}