@article{15577,
  keywords = {Animals, Cells, Cultured, Female, Hot Temperature, Immunity, Cellular, Immunization, Passive, leprosy, Lymphocyte Activation, Lymphocytes, Mice, Mice, Inbred BALB C, Mycobacterium leprae, Skin Tests},
  author = {Graham L and Navalkar R G},
  title = {Evaluation of Mycobacterium leprae immunogenicity via adoptive transfer studies.},
  abstract = {<p>The immune response of mice to live, heat-killed, or autoclaved Mycobacterium leprae was investigated. After sensitization with 10(7) organisms in each group, recipient mice were transfused with the sensitized splenocytes 28 days later. A selected number of these mice were infected with 5 X 10(3) M. leprae, and the remaining animals were sacrificed at scheduled intervals for evidence of cell-mediated immunity to the M. leprae cell extract. Data from these and the bacteriological assays showed that all three materials induce cell-mediated immunity and also extend protection against the M. leprae challenge but not against a Listeria monocytogenes challenge. Adoptive immunity against M. leprae was expressed equally effectively in both non-irradiated animals and those sublethally (500 R) irradiated. This study reveals that, after adoptive transfer of immunity, a bacillary restriction occurs with concomitant onset of delayed hypersensitivity and that the protection observed could be specifically directed against an M. leprae challenge.</p>},
  year = {1984},
  journal = {Infection and immunity},
  volume = {43},
  pages = {79-83},
  month = {1984 Jan},
  issn = {0019-9567},
  language = {eng},
}