@article{15576,
  keywords = {Antigens, Bacterial, Cell Division, Cells, Cultured, HLA-DR3 Antigen, Histocompatibility Antigens Class II, Humans, Lepromin, leprosy, Monocytes, Mycobacterium leprae, T-Lymphocytes},
  author = {Eden W and Elferink B G and Vries R R and Leiker DL and Rood J J},
  title = {Low T lymphocyte responsiveness to Mycobacterium leprae antigens in association with HLA-DR3.},
  abstract = {<p>The type of leprosy which develops after infection with Mycobacterium leprae is influenced by the presence or absence of HLA-DR3, as has been demonstrated in an ethnic group originating from Surinam. In the present study we investigated in this same ethnic group the role of HLA-DR, and of HLA-DR3 in particular, in monocyte-T cell interactions during leprosy specific proliferative responses in vitro. HLA-DR3 heterozygous T cells from tuberculoid leprosy patients were cultured with antigen and either HLA-DR3 positive or HLA-DR3 negative homozygous HLA-DR compatible allogeneic monocytes as antigen presenting cells (APCs). T cell proliferative responses with DR3 homozygous monocytes as APCs, were observed to be decreased as compared to T cell proliferative responses with DR3 negative homozygous monocytes as APCs. Furthermore, although the leprosy specific monocyte-T cell interactions were shown to be restricted for HLA-DR, in the anti-MLW-1 response HLA-DR3 appeared to function as a restricting element poorly or not at all. These observations may imply, that an in vitro correlate has been found for an (HLA associated) genetic control of leprosy in vivo.</p>},
  year = {1984},
  journal = {Clinical and experimental immunology},
  volume = {55},
  pages = {140-8},
  month = {1984 Jan},
  issn = {0009-9104},
  url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1535784/pdf/clinexpimmunol00148-0149.pdf},
  language = {eng},
}