@article{15466,
  keywords = {Adult, Aged, Antibodies, Antibodies, Antinuclear, Antigen-Antibody Complex, B-Lymphocytes, Dinitrophenols, Haptens, Humans, leprosy, Lymphocyte Activation, Middle Aged},
  author = {Furukawa F and Ohshio G and Ozaki M and Hamashima Y},
  title = {Anti-hapten antibodies and autoantibodies in Japanese patients with lepromatous leprosy.},
  abstract = {<p>In the sera of patients with lepromatous leprosy anti-DNP antibodies were detected in order to determine the mode of polyclonal B-cell activation. Anti-DNP antibodies were found in 30% of the patients with active lepromatous leprosy and in 8% of those with inactive lepromatous leprosy. The level of anti-DNP antibodies in active patients was significantly higher than the level in inactive patients and control. However, the presence of anti-DNP antibodies was unrelated to the production of circulating immune complexes and antinuclear antibodies. These results suggest that polyclonal B-cell activation might occur but that the B-cell clones stimulated by M. leprae are different from patient to patient.</p>},
  year = {1984},
  journal = {Archives of dermatological research},
  volume = {276},
  pages = {195-8},
  month = {1984},
  issn = {0340-3696},
  doi = {10.1007/bf00414019},
  language = {eng},
}