@article{15454, keywords = {Adolescent, Adult, Aged, Child, Female, Granuloma, Humans, leprosy, Male, Middle Aged, Skin, T-Lymphocytes}, author = {Wallach D and Flageul B and Bach M A and Cottenot F}, title = {The cellular content of dermal leprous granulomas: an immuno-histological approach.}, abstract = {
An indirect immunofluorescence technique with monoclonal antibodies has been used to identify T cells, T helper cells, T suppressor cells, and granulocytes in the dermal granulomas of 22 patients with leprosy. In tuberculoid leprosy, T helper cells predominated and T suppressor cells were located at the periphery of well-circumscribed granulomas. In lepromatous leprosy, the two subsets of T cells were numerous in treated patients. In ENL lesions, T cells were more numerous and T helper cells predominated. Enumerations of the T cell subsets in the dermis and in the blood showed similar changes, but these changes were quantitatively more marked in the dermal granulomas.
}, year = {1984}, journal = {International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association}, volume = {52}, pages = {318-26}, month = {1984 Sep}, issn = {0148-916X}, language = {eng}, }