@article{15396,
  keywords = {Antibodies, Monoclonal, Fluorescent Antibody Technique, Histocompatibility Antigens Class II, HLA-DR Antigens, Humans, leprosy, Macrophages, Mycobacterium leprae, Phenotype, Skin, T-Lymphocytes, T-Lymphocytes, Helper-Inducer, T-Lymphocytes, Regulatory},
  author = {Van Voorhis W C and Kaplan G and Sarno E N and Horwitz M A and Steinman R M and Levis W R and Nogueira N and Hair L S and Gattass C R and Arrick B A and Cohn Z A},
  title = {The cutaneous infiltrates of leprosy: cellular characteristics and the predominant T-cell phenotypes.},
  abstract = {<p>We report on the characteristics of cells in the cutaneous lesions and blood of 21 patients with lepromatous, tuberculoid, and intermediate forms of leprosy. A large proportion of the infiltrates in lepromatous lesions consist of macrophages heavily parasitized with Mycobacterium leprae. The T cells in the lesions are devoid of OKT4/Leu 3a-positive ("helper") cells and consist almost exclusively of OKT8/Leu 2a-positive ("suppressor") populations. In contrast, the tuberculoid infiltrates contain well-organized epithelioid and giant-cell granulomas and only remnants of bacilli, and the predominant T cell is from the OKT4/Leu 3a-positive subset. In both tuberculoid and lepromatous infiltrates, T cells and macrophages expressed HLA-DR antigen. No marked alteration in the distribution of blood T-cell phenotypes was noted. We conclude that there is a marked difference between T-cell subsets in lepromatous and tuberculoid infiltrates, which may influence the microbicidal activity of macrophages in the lesions.</p>},
  year = {1982},
  journal = {The New England journal of medicine},
  volume = {307},
  pages = {1593-7},
  month = {1982 Dec 23},
  issn = {0028-4793},
  doi = {10.1056/NEJM198212233072601},
  language = {eng},
}