@article{15308,
  keywords = {Clofazimine, Female, Humans, leprosy, Male, Models, Biological},
  author = {Feng P C and Fenselau C C and Jacobson R R},
  title = {Metabolism of clofazimine in leprosy patients.},
  abstract = {<p>We have identified two metabolites of clofazimine (B663; Lamprene; 3-(p-chloroanilino)-10-(p-chlorophenyl)-2,10-dihydro-2-isopropyliminophenazine)  in our initial investigation of its metabolism in leprosy patients. Based on mass, ultraviolet, and visible spectrometry, we characterized an unconjugated (metabolite I, 3-(p-hydroxyanilino)-10-(p-chlorophenyl)-2,10-dihydro-2-isopropyliminophenazine ) and a conjugated (metabolite II, 3-(beta-D-glucopyranosiduronic acid)-10-(p-chlorophenyl)-2,10-dihydro-2-isopropyliminophenazine) metabolite from the urine of patients. Both metabolites were red in color, similar to clofazimine; however, both were considerably more polar than the parent drug. We suggest that metabolite I was formed by a hydrolytic dehalogenation reaction, and metabolite II by hydrolytic deamination followed by glucuronidation.</p>},
  year = {1981},
  journal = {Drug metabolism and disposition: the biological fate of chemicals},
  volume = {9},
  pages = {521-4},
  month = {1981 Nov-Dec},
  issn = {0090-9556},
  language = {eng},
}