@article{15283,
  keywords = {Adult, Antigens, Bacterial, B-Lymphocytes, Dose-Response Relationship, Immunologic, Epitopes, Female, Humans, Hydrocortisone, Immunoglobulin M, Indomethacin, leprosy, Lymphocyte Activation, Male, Middle Aged, Mycobacterium, T-Lymphocytes},
  author = {Fleming B and Rook G A},
  title = {T-cell-dependent polyclonal activation by soluble mycobacterial extracts of B cells in peripheral blood mononuclear cell populations from leprosy patients and normal donors.},
  abstract = {<p>Soluble extracts of ultrasonically disrupted mycobacteria (including Mycobacterium leprae) cause strong T-cell-dependent, Cyclosporin A-sensitive, polyclonal B-cell activation, in human peripheral blood mononuclear cell preparations. It is not enhanced by cortisol. Cells from cases of lepromatous leprosy show no polyclonal B-cell activation in the presence of extracts of M. leprae, although they respond normally to other mycobacterial species. The polyclonal B-cell activation response to the M. leprae extract, of a small group of normal leprosy contacts, was reduced relative to that of non-contacts.</p>},
  year = {1982},
  journal = {Immunology},
  volume = {47},
  pages = {589-95},
  month = {1982 Dec},
  issn = {0019-2805},
  language = {eng},
}