@article{14070,
  keywords = {Aniline Compounds, Anti-Infective Agents, Humans, Imines, leprosy, Phenazines, Sulfonamides, Sulfones, Thalidomide, Urea},
  author = {Convit J and Browne S G and Languillon J and Pettit J H and Ramanujam K and Sagher F and Sheskin J and Tarabini G and DE SOUZA LIMA L and Tolentino J G and Waters M F and Bechelli L M and Martinez Dominguez V},
  title = {Therapy of leprosy.},
  abstract = {<p>The latest developments and ideas in the therapy of leprosy are discussed, the need for long-term studies being stressed. The therapeutic efficacy and effective dosages of some sulfones (especially diaphenylsulfone), thiambutosine and long-acting sulfonamides such as sulfamethoxine and sulfalene, are considered. The possibilities for two newer drugs, 4,4'-diacetyldiaminodiphenylsulfone and clofazimine (B-663), both still in the early stages of evaluation, are also described and the potential value of thalidomide in treatment of the lepra reaction is discussed. The authors make a number of recommendations for controlled trials and lines of investigation and, in particular, favour a biochemical approach to the correction of defective host defences. Diaphenylsulfone is still considered the drug of choice for use in the therapy of leprosy.</p>},
  year = {1970},
  journal = {Bulletin of the World Health Organization},
  volume = {42},
  pages = {667-72},
  month = {1970},
  issn = {0042-9686},
  language = {eng},
}