@article{1313,
  keywords = {Chromosome Mapping, Chromosomes, Human, Pair 20, Female, Genetic Markers, Genetic Predisposition to Disease, Genetics, Population, Humans, India, leprosy, Male, Microsatellite Repeats, Mycobacterium leprae},
  author = {Tosh K and Meisner S and Siddiqui RM and Balakrishnan K and Ghei S and Golding M and Sengupta U and Pitchappan R and Hill A},
  title = {A region of chromosome 20 is linked to leprosy susceptibility in a South Indian population.},
  abstract = {<p>A major susceptibility locus for leprosy has recently been mapped on chromosome 10 (10p13) by genome-wide linkage analysis. Microsatellite markers from this genome screen that showed suggestive evidence of linkage to leprosy were evaluated in an additional 140 families with affected sib pairs. A second region of linkage has thus been identified on chromosome 20 (20p12). The peak of linkage lies at marker D20S115, which has a significant single-point maximum logarithm of odds score of 3.48 (P=.00003). Transmission disequilibrium testing of the microsatellite markers in 20p12 showed that the marker D20S835 is associated with protection against leprosy (P=.021), which suggests that a locus controlling susceptibility lies close to this marker.</p>},
  year = {2002},
  journal = {The Journal of infectious diseases},
  volume = {186},
  pages = {1190-3},
  month = {2002 Oct 15},
  issn = {0022-1899},
  doi = {10.1086/343806},
  language = {eng},
}