@article{12767,
  keywords = {Adolescent, Adult, Animals, Blastocyst, Dapsone, Dogs, Dose-Response Relationship, Drug, Ethnic Groups, Female, Humans, In Vitro Techniques, Infant, Newborn, Lectins, leprosy, Lymphocyte Activation, Lymphocytes, Male},
  author = {Beiguelman B and Pisam R C},
  title = {Effect of DDS on phytohemagglutinin-induced lymphocyte transformation.},
  abstract = {<p>The influence of DDS on PHA-induced lymphocyte transformation was investigated in leukocyte cultures from two samples of healthy Caucasoid individuals. In one sample the sulfone-treated cultures differed from the controls in that they contained 0.4 mug/ml of other sample, the treated cultures contained DDS in concentrations of 4 mug/ml, 8 mug/ml and 16 mug/ml. The frequency of lymphocyte transformation induced by PHA was significantly reduced by DDS in all concentrations used. The data obtained are a strong indication that the plasma levels of dapsone among leprosy patients may contribute to the depression of the blastogenic capacity of their lymphocytes when stimulated by PHA.</p>},
  year = {1974},
  journal = {International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association},
  volume = {42},
  pages = {412-15},
  month = {1974 Oct-Dec},
  issn = {0148-916X},
  url = {http://ila.ilsl.br/pdfs/v42n4a04.pdf},
  language = {eng},
}