@article{12750,
  keywords = {Acedapsone, Adult, Child, Dapsone, Drug Resistance, Microbial, Humans, leprosy, Micronesia, Patient Compliance, Recurrence},
  author = {Russell D A and WORTH R M and Jano B and Fasal P and Shepard C C},
  title = {Acedapsone in the prevention of leprosy: field trial in three high prevalence villages in Micronesia.},
  abstract = {<p>The 1,659 non-leprous people in a Micronesian population experiencing an annual leprosy incidence rate of about 7/1,000 were offered 15 acedapsone (DADDS) injections during 1967--1970 for leprosy prevention purposes. Subsequent annual surveillance showed an initial cessation of new cases during the 3-year DADDS campaign, followed by a resumption of cases thereafter at a yearly level of about 2/1,000 with a longer pause and slower rise among those who received the full regimen. A secondary wave of cases that has occurred since 1973 among children born after 1968 shows that post-campaign transmission occurred, probably principally from relapsing multibacillary cases with onset before the campaign. Recommendations are made for a balanced, long-term control program with DADDS preventive treatment limited to contacts of multibacillary cases.</p>},
  year = {1979},
  journal = {The American journal of tropical medicine and hygiene},
  volume = {28},
  pages = {559-63},
  month = {1979 May},
  issn = {0002-9637},
  language = {eng},
}