@article{1230,
  keywords = {Antibodies, Antineutrophil Cytoplasmic, Autoimmune Diseases, HLA-A1 Antigen, HLA-B Antigens, HLA-B40 Antigen, Humans, Immunogenetics, India, leprosy, Malaria, Vasculitis},
  author = {Shankarkumar U and Ghosh K and Pradhan V D and Badakere S S and Mohanty D},
  title = {Immunogenetic association in patients with antineutrophil cytoplasmic antibodies (ANCA) from Mumbai, Maharashtra, India.},
  abstract = {<p>Considerable genetic evidence exit for ANCA-associated vasculitis and pathogenesis. HLA A and B alleles identified serologically from 84 ANCA-positive patients were compared with 101 controls. Further subtyping were done in the 27 "pauci-immune" vasculitis patients using the polymerase chain reaction based PCR-SSOP technique and compared with controls (67). The results revealed that HLA A1 (OR=4.00; p value 2.72E-05), B17 (OR=3.38; p value 0.0008) and HLA B40 (OR=2.74; p value 0.001) were significantly increased among ANCA-positive patients when compared with the controls. Further, the molecular subtypes A*0101 (OR=5.04; p value 0.0005), B*5801 (OR=4.47; p value 0.0002) and haplotype A*0101-B*5801 (OR=4.47; p value 0.0001) were significantly increased among the autoimmune patients. The study revealed that HLA A1, B17 and B40 alleles are associated in production of antineutrophil autoantibodies and A*0101-B*5801 haplotype is significantly associated with autoimmune diseases and they may be invariably involved in disease pathogenesis in India.</p>},
  year = {2005},
  journal = {Journal of autoimmunity},
  volume = {24},
  pages = {227-33},
  month = {2005 May},
  issn = {0896-8411},
  doi = {10.1016/j.jaut.2005.01.009},
  language = {eng},
}