@article{1222,
  keywords = {Alleles, Case-Control Studies, DNA Primers, Haplotypes, HLA-DR Antigens, Humans, Immunogenetics, India, leprosy, Mycobacterium Infections, Oligonucleotide Probes, polymerase chain reaction, Tuberculosis, Pulmonary},
  author = {Singh M and Balamurugan A and Katoch K and Sharma S K and Mehra N K},
  title = {Immunogenetics of mycobacterial infections in the North Indian population.},
  abstract = {<p>Several lines of evidence highlight the genetic basis of risk to develop mycobacterial diseases. Human leukocyte antigen (HLA)-DR2 alleles (DRB1*1501 and DRB1*1502) have been found to be strongly associated with mycobacterial disease, especially the more severe forms such as lepromatous leprosy and multidrug-resistant pulmonary tuberculosis. In this study, DNA-based high-resolution typing techniques of polymerase chain reaction-sequence-specific oligonucleotide probe were used to determine the distribution of HLA-DR/DQ alleles in patients with leprosy and pulmonary tuberculosis. Analysis of different DR2 subtypes based on valine/glycine dimorphism at codon beta86 in pocket 1 of HLA-DR showed an inverse relationship of DR2 alleles with V/G as the severity of disease increased both in leprosy and in pulmonary tuberculosis.</p>},
  year = {2007},
  journal = {Tissue antigens},
  volume = {69 Suppl 1},
  pages = {228-30},
  month = {2007 Apr},
  issn = {0001-2815},
  doi = {10.1111/j.1399-0039.2006.77311.x},
  language = {eng},
}