@article{11954,
  keywords = {Adjuvants, Immunologic, Adult, BCG Vaccine, Cimetidine, Clinical Trials as Topic, Double-Blind Method, Female, Humans, Lepromin, leprosy, Leukocyte Count, Lymphocyte Activation, Lymphocytes, Male, Middle Aged, Phytohemagglutinins, Random Allocation, Skin Tests, Tuberculin Test},
  author = {Brown A E and Nelson K E and Makonkawkeyoon S and Vithayasai V and Scollard D M and Bullock W E},
  title = {A study of the immunological effects of cimetidine in patients with lepromatous leprosy.},
  abstract = {<p>To test the capacity of cimetidine to enhance cellular immunity in patients with lepromatous leprosy (LL), cimetidine was given for one month to 29 inactive LL patients and 3 active LL patients. Immune function was monitored with skin tests (lepromin, PPD, candida, and trichopytin), lymphocyte transformation tests (phytohemagglutinin, BCG, and Dharmendra lepromin), and quantitation of peripheral blood lymphocyte subpopulations. A small but significant "booster" response to PPD was the only change observed in the study of patients with inactive disease, and leprosy-related reactions did not occur. In the few active LL patients studied, neither immune enhancement nor leprosy-related reactions were observed. The results of this investigation suggest that cimetidine can be used safely in patients with inactive lepromatous leprosy.</p>},
  year = {1985},
  journal = {International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association},
  volume = {53},
  pages = {559-64},
  month = {1985 Dec},
  issn = {0148-916X},
  language = {eng},
}