@article{11845,
  keywords = {Animals, Disease Models, Animal, Immune Tolerance, Immunity, Cellular, Immunosuppression, leprosy, Macrophages, Mice, Mice, Inbred BALB C, Mycobacterium Infections, Mycobacterium lepraemurium},
  author = {Preston P M},
  title = {Serum from infected mice suppresses macrophage-mediated immunity in Mycobacterium lepraemurium infection: a model for imparied macrophage immunity in human leprosy.},
  abstract = {<p>Differing patterns of Mycobacterium lepraemurium infection in inbred strains of mice are of interest as a model system for studying mycobacterial infections of man, e.g. M. leprae, which present with a spectrum of clinical disease. In vitro, macrophages from both resistant (C57B1) and susceptible (BALB/c) inbred strains of mice can be shown to be equally effective in controlling multiplication of M. lepraemurium. Experiments presented here show that in vivo, the potential mechanisms of macrophage-mediated immunity are suppressed in the susceptible (BALB/c) strain of mouse by a soluble factor(s) present in the serum and the peritoneal fluid of infected mice.</p>},
  year = {1979},
  journal = {Transactions of the Royal Society of Tropical Medicine and Hygiene},
  volume = {73},
  pages = {212-5},
  month = {1979},
  issn = {0035-9203},
  doi = {10.1016/0035-9203(79)90215-3},
  language = {eng},
}