@article{11750, keywords = {Animals, Armadillos, Biopsy, Epidermis, Histocytochemistry, leprosy, Macrophages, Microscopy, Electron, Remission, Spontaneous, Time Factors, Xenarthra}, author = {Iushchenko A A and Vishnevetskiĭ F E}, title = {[Histochemical study of reverse reactions in experimental leprosy in armadillos].}, abstract = {

Morphological and histochemical characteristics of reverse reactions in M. leprae-infected armadillos are reviewed. The reverse reactions develop in generalized lepromatous disease and are characterized by a dramatic decrease in mycobacterial macrophage load and the appearance of lymphocytes, epithelioid and giant multinuclear cells with peripheral nucleus distribution. Histochemical investigation has shown a decrease in the activity of redox enzymes and alpha-naphthyl acetate esterase and an increase in beta-glucuronidase activity. The reverse reactions in the liver are accompanied by hepatic granuloma and hepatocyte destruction.

}, year = {1987}, journal = {Biulleten' eksperimental'noi biologii i meditsiny}, volume = {103}, pages = {376-80}, month = {1987 Mar}, issn = {0365-9615}, language = {rus}, }