@article{11708,
  keywords = {Animals, Armadillos, Dapsone, Disease Models, Animal, Female, leprosy, Male, Xenarthra},
  author = {Dhople A M},
  title = {Armadillo as a model for studying chemotherapy of leprosy: preliminary studies.},
  abstract = {<p>In order to determine the suitability of the armadillos as a model of human leprosy for chemotherapeutic studies, especially in evaluating newer anti-leprosy drugs, uninfected Armadillos were used to study the metabolic disposition of DDS. Serum DDS levels ranged from 500 ng/ml at 3 hours to 13 ng/ml at 96 hours after intravenous administration of DDS (1 mg/kg). In an ad libitum feeding trial of DDS it was found that the level of serum DDS varied according to the dose of DDS, and even at a dose of 0.0001%, the animals maintained MIC of DDS against M. leprae. Finally, it was demonstrated that armadillos acetylate DDS to MADDS and 7-9% of DDS is acetylated by armadillos.</p>},
  year = {1986},
  journal = {Indian journal of leprosy},
  volume = {58},
  pages = {19-28},
  month = {1986 Jan-Mar},
  issn = {0254-9395},
  language = {eng},
}