@article{11683,
  keywords = {Acedapsone, Adult, Animals, Dapsone, Half-Life, Humans, leprosy, Mice, Time Factors},
  author = {George J and Balakrishnan S},
  title = {Blood dapsone levels in leprosy patients treated with acedapsone.},
  abstract = {<p>The metabolism of the repository drug acedapsone (DADDS,4,4'-diacetyldiaminodiphenyl sulfone) was studied in 15 individuals receiving 225 mg of DADDS, intramuscularly for a period of 75 days. Plasma levels of DDS were determined on the 2nd, 7th, 15th, 30th, 60th and 75th day after administration of the drug by spectrophoto-fluorometric technique. The mean peak levels of DDS (85.36 ng/ml) were noticed on 7th day followed by a gradual decrease in DDS concentration. The mean half-life level (44.53 ng/ml) of DDS were observed around the 15th day. The mean DDS level for the entire period of observation after one dose was 41.95 ng/ml. On the 75th day, the DDS level reached the minimum value of 14.76 ng/ml which was still about 5 times more than the minimal inhibitory concentration (MIC) level of DDS against M. leprae (3 ng/ml). The results are discussed.</p>},
  year = {1986},
  journal = {Indian journal of leprosy},
  volume = {58},
  pages = {401-6},
  month = {1986 Jul-Sep},
  issn = {0254-9395},
  language = {eng},
}