@article{11633,
  keywords = {Antigens, Bacterial, Humans, leprosy, Lymphocyte Activation, Lymphocyte Cooperation, Macrophages, Mycobacterium leprae, T-Lymphocytes},
  author = {Hirschberg H},
  title = {The role of macrophages in the lymphoproliferative response to Mycobacterium leprae in vitro.},
  abstract = {<p>Peripheral blood lymphocytes from patients suffering from lepromatous leprosy do not normally react in vitro to stimulation by Mycobacterium leprae antigens. In contrast, we found that T cells from non-responding patients in combination with macrophages from responding patients or healthy contacts did respond well to M. leprae. Conversely, T cells from responding patients or healthy contacts in combinations with macrophages from non-responding patients failed to respond. It seems, therefore, that the lack of response normally observed in in vitro tests using cells from lepromatous leprosy patients is due to a failure of their macrophages to present M. leprae antigens in an immunogenic form.</p>},
  year = {1978},
  journal = {Clinical and experimental immunology},
  volume = {34},
  pages = {46-51},
  month = {1978 Oct},
  issn = {0009-9104},
  language = {eng},
}