@article{11534,
  keywords = {Animals, leprosy, Macrophages, Mice, Mice, Inbred CBA, Mycobacterium leprae, Phagocytosis, Time Factors},
  author = {Chandi S M and Job C K},
  title = {The early cellular response to M. leprae. An ultrastructural study.},
  abstract = {<p>The ultrastructural changes that develop in mouse peritoneal macrophages from 10 minutes up to 14 weeks after exposure to Mycobacterium leprae are presented. Phagocytosis occurred by a process of engulfment by cytoplasmic processes and incorporation into a phagosome, into which lysosomal enzymes were subsequently introduced. Electron transparent zones (E.T.Z.) were not observed around phagocytosed bacilli in this study, however discrete droplets of lipid-like material appeared in the cytoplasm of macrophages, between 2 and 4 weeks after ingestion of the micro-organisms. Phagosomes with double limiting membranes were observed in macrophages harvested as early as 40 minutes after exposure to M. leprae, contrary to the observations of Evans and Levy (1972).</p>},
  year = {1978},
  journal = {Leprosy in India},
  volume = {50},
  pages = {345-57},
  month = {1978 Jul},
  issn = {0024-1024},
  language = {eng},
}