@article{11343,
  keywords = {Animals, Foot, leprosy, Mice, Mice, Inbred CBA, Mycobacterium leprae},
  author = {BAPAT C V and Modak M S},
  title = {Growth of the ICRC bacilli in the foot-pad of mice.},
  abstract = {<p>The ICRC bacilli are acid-fast bacilli cultivated from M. leprae isolates of lepromatous tissue. The ICRC bacilli from C-44 in the conditioned medium were subjected to foot-pad test, in both normal and T/900r mice. The bacilli exhibits a limited multiplication in normal mice while a continuous growth in T/900r mice. The maximum yield for normal and T/900r mice was 10(7) and 10(9)/foot-pad, respectively. The infiltration of voluntary muscle tissue as the main localization site was common for both normal and T/900r mice with evidence of dissemination in the latter. The spread of AFB to sciatic nerve, induction of liver granuloma and the foot-drop was observed only in T/900r mice. These experiments show that the growth of ICRC bacilli in mouse foot-pad is very similar to that of M. leprae confirming a test for identification.</p>},
  year = {1978},
  journal = {Leprosy in India},
  volume = {50},
  pages = {144-55},
  month = {1978 Apr},
  issn = {0024-1024},
  language = {eng},
}