@article{11262,
  keywords = {Antigens, Bacterial, Concanavalin A, Dose-Response Relationship, Immunologic, Glycolipids, Humans, Immune Tolerance, In Vitro Techniques, leprosy, Lymphocyte Activation, Mycobacterium leprae},
  author = {Prasad H K and Mishra R S and Nath I},
  title = {Phenolic glycolipid-I of Mycobacterium leprae induces general suppression of in vitro concanavalin A responses unrelated to leprosy type.},
  abstract = {<p>Using a costimulant assay, in vitro Con A responses of patients across the leprosy spectrum were found to be markedly suppressed by phenolic glycolipid-I (PGL-I), a unique antigen of M. leprae. The degree of inducible suppression as well as the number of leprosy patients showing suppression of mitogenic responses was higher with PGL-I as compared with integral M. leprae (p less than 0.05 to less than 0.01). Both untreated lepromatous (60%) as well as tuberculoid leprosy (67%) patients showed significant suppression ranging from 13 to 64% and 12 to 79%, respectively. Thus, PGL-I appears to have a universal suppressive effect on Con A responses and is unlikely to play a central role in determining the leprosy spectrum.</p>},
  year = {1987},
  journal = {The Journal of experimental medicine},
  volume = {165},
  pages = {239-44},
  month = {1987 Jan 01},
  issn = {0022-1007},
  doi = {10.1084/jem.165.1.239},
  language = {eng},
}