@article{11254,
  keywords = {Adult, Animals, Armadillos, Bacterial Vaccines, Female, Humans, leprosy, Lymphocyte Activation, Lymphocytes, Male, Mycobacterium leprae, Vaccination},
  author = {Gill H K and Mustafa A S and Godal T},
  title = {In vitro proliferation of lymphocytes from human volunteers vaccinated with armadillo-derived, killed M. leprae.},
  abstract = {<p>A killed, armadillo-derived Mycobacterium leprae vaccine was examined for its ability to induce cell-mediated responsiveness in purified protein derivative (PPD)-positive volunteers residing in a nonendemic country using the lymphocyte transformation test (LTT). A marked increase in the proliferative responses to a M. leprae-soluble antigen preparation was observed in the two groups which were vaccinated with the highest doses of the vaccine, i.e., 1.5 X 10(8) and 5 X 10(8) bacilli. This increase was observed in both groups 3 months after vaccination, and persisted for the study period of 1 year. The in vitro proliferative responses to whole bacilli, of both armadillo and human origin, showed a similar but smaller increase 3 months after vaccination. Some enhancement of responses to cross-reactive antigens, such as PPD, and to unrelated antigens such as streptokinase-streptodornase, tetanus toxoid and diphtheria toxoid, was also observed. Thus, the LTT revealed that while the killed M. leprae vaccine induced a specific cell-mediated response to M. leprae, it was also responsible for a nonspecific immune-enhancement effect in healthy volunteers.</p>},
  year = {1987},
  journal = {International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association},
  volume = {55},
  pages = {30-5},
  month = {1987 Mar},
  issn = {0148-916X},
  language = {eng},
}