@article{10753,
  keywords = {Cell Movement, Hemophilia A, Humans, Hypersensitivity, Delayed, leprosy, Lung Diseases, Obstructive, Skin, T-Lymphocytes, Tuberculin Test, Tuberculosis, Pulmonary},
  author = {Beck J S and Morley S M and Lowe J G and Brown R A and Grange J M and Gibbs J H and Potts R C and Kardjito T},
  title = {Diversity in migration of CD4 and CD8 lymphocytes in different microanatomical compartments of the skin in the tuberculin reaction in man.},
  abstract = {<p>The lymphocytes in the perivascular foci of tuberculin skin tests have a similar CD4:CD8 ratio to those in the peripheral blood, suggesting that these subsets do not show bias in their initial emigration. By contrast, the diffusely infiltrating lymphocytes show a relative preponderance of CD4 cells which is progressively greater in successive 250 micron layers into the dermis. A generally similar pattern is seen in healthy controls and in patients with untreated pulmonary tuberculosis, treated leprosy, haemophilia A and chronic obstructive lung disease (COLD) patients treated with prednisolone, but the gradient of increasing CD4:CD8 ratio with depth into the dermis is significantly less steep in patients with tuberculosis, haemophilia and prednisolone-treated COLD than in the healthy controls. Selective migration results in a relative preponderance of CD4 cells in the diffuse infiltrate and it is suggested that this is a mechanism likely to potentiate defensive reaction to Mycobacterium tuberculosis: any deficiency in selective migration may make immunological defences less effective and so contribute to the chronicity of the lesions of tuberculosis.</p>},
  year = {1988},
  journal = {British journal of experimental pathology},
  volume = {69},
  pages = {771-80},
  month = {1988 Dec},
  issn = {0007-1021},
  url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2013285/pdf/brjexppathol00006-0017.pdf},
  language = {eng},
}