@article{10688,
  keywords = {Aged, Aged, 80 and over, Amyloidosis, China, Female, Humans, Leprosy, Borderline, Leprosy, lepromatous, Leprosy, Tuberculoid, Malaysia, Male, Middle Aged, Serum Amyloid A Protein},
  author = {Looi L M and Jayalakshim P and Lim K J and Rajagopalan K},
  title = {An immunohistochemical and morphological study of amyloidosis complicating leprosy in Malaysian patients.},
  abstract = {<p>Congo red screening of tissue blocks from 37 consecutive autopsies on leprosy patients revealed 7 cases of systemic amyloidosis, indicating a prevalence rate of 19%. 5 were males and 2 females. All were ethnic Chinese. Their ages ranged from 52 to 85 years with a mean of 69 years. Six had lepromatous leprosy while the remaining 1 had tuberculoid leprosy. In all 7 cases, the amyloid was AA in type, being permanganate-sensitive and immunoreactive with anti-human AA protein antiserum. Hepatic deposition was limited to blood vessels, a pattern typical of AA (secondary) amyloidosis. With regard to renal involvement, 4 showed a predominantly vascular pattern of infiltration while 3 exhibited the more ominous glomerular pattern. Three died of chronic renal failure and 2 of congestive cardiac failure attributable to renal and cardiac amyloidosis respectively. One patient succumbed to septicaemia and the remaining 1 to acute myocardial infarction. AA amyloidosis remains a serious and significant complication of leprosy among Malaysians.</p>},
  year = {1988},
  journal = {Annals of the Academy of Medicine, Singapore},
  volume = {17},
  pages = {573-8},
  month = {1988 Oct},
  issn = {0304-4602},
  language = {eng},
}