@article{10549, keywords = {Blotting, Western, Enzyme-Linked Immunosorbent Assay, HIV Antibodies, HIV Antigens, HIV Core Protein p24, HIV-1, Humans, India, leprosy, Retroviridae Proteins, Tuberculosis, Pulmonary}, author = {Shivraj L and Patil S A and Girdhar A and Sengupta U and Desikan K V and Srinivasan H}, title = {Antibodies to HIV-1 in sera from patients with mycobacterial infections.}, abstract = {

Sera from 478 persons (348 leprosy patients, 33 tuberculosis patients, 29 healthy contacts of leprosy patients, 38 normal healthy Indians, and 30 normal healthy Europeans) were screened for anti-HIV-1 IgG antibodies by ELISA. None was positive. In addition, 132 samples (from 43 leprosy patients, 21 tuberculosis patients, 5 healthy contacts of leprosy patients, 33 normal healthy Indians, and 30 normal healthy Europeans) were also tested by Western blot assay for anti-HIV-1 IgG antibodies. Only 1 of the 63 healthy subjects expressed a prominent p17 band. One or more bands were found in 44 (leprosy patients 33/43, tuberculosis patients 7/21, and leprosy contacts 4/5) of the remaining 69 sera. Antibody to the HIV-1-specific antigen p24 was expressed by 17 of these subjects (14/43 leprosy patients, 1/21 tuberculosis patients, and 2/5 leprosy contacts), either as a single band or in combination with other bands. This raises the possibility of a common antigenic pattern between HIV-1 and mycobacteria, especially Mycobacterium leprae.

}, year = {1988}, journal = {International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association}, volume = {56}, pages = {546-51}, month = {1988 Dec}, issn = {0148-916X}, language = {eng}, }