@article{10540, keywords = {Antigens, Bacterial, Enzyme-Linked Immunosorbent Assay, Glycolipids, Glycoproteins, Humans, Immunodiffusion, leprosy, Methylglucosides, Methylglycosides, Mycobacterium leprae, Serologic Tests}, author = {Cho S N and Chatterjee D and Brennan P J}, title = {A simplified serological test for leprosy based on a 3,6-di-O-methylglucose-containing synthetic antigen.}, abstract = {

The recent advent of synthetic antigens containing the Mycobacterium leprae-specific epitope, 3,6-di-O-methyl-beta-D-glucopyranoside, has allowed the development of simple specific serological tests for leprosy. The incorporation of one such product, 8-carbonyloctyl O-[4-O-(3,6-di-O-methyl-beta-D-glucopyranosyl)-alpha-L- rhamnopyranoside]-BSA, into a simple "spot" test, diffusion-in-gel enzyme-linked immunosorbent assay (ELISA), allowed an over 90% detection rate of untreated lepromatous leprosy, and the results showed good concordance with conventional ELISA based on the native phenolic glycolipid I.

}, year = {1986}, journal = {The American journal of tropical medicine and hygiene}, volume = {35}, pages = {167-72}, month = {1986 Jan}, issn = {0002-9637}, doi = {10.4269/ajtmh.1986.35.167}, language = {eng}, }