@article{10435, keywords = {Antigen-Presenting Cells, Antigens, Bacterial, Antigens, Viral, Herpesvirus 4, Human, Humans, Interferon-gamma, leprosy, Mycobacterium leprae}, author = {Lindh J and Anderson U and Britton S and De Ley M}, title = {A single cell assay for the study of gamma-interferon formation in leprosy patients.}, abstract = {
The number of gamma-interferon producing cells in the peripheral blood of leprosy (LL and BT) patients and controls was studied by the reversed protein A plaque assay before and after exposure in vitro to Mycobacterium leprae bacilli and Epstein-Barr virus (EBV). The level of spontaneous gamma-interferon production was significantly higher in BT patients compared to LL patients and controls. Mycobacterium leprae induced a specific gamma-interferon response in lymphocytes from BT patients and from healthy contacts whereas in LL patients and non-exposed controls the response was low or non-existing. There were no significant differences in the gamma-interferon response to EBV between the above groups.
}, year = {1987}, journal = {Clinical and experimental immunology}, volume = {67}, pages = {51-4}, month = {1987 Jan}, issn = {0009-9104}, url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1542566/pdf/clinexpimmunol00112-0060.pdf}, language = {eng}, }