@article{10434, keywords = {Adolescent, Adult, Biopsy, Dapsone, Female, Humans, leprosy, Male, Motor Neurons, Neural Conduction, Peripheral Nervous System Diseases, Poisoning, Tibial Nerve}, author = {Sirsat A M and Lalitha V S and Pandya S S}, title = {Dapsone neuropathy--report of three cases and pathologic features of a motor nerve.}, abstract = {
We report the clinical features, electrophysiologic findings, and dapsone and isoniazid excretion studies in three young people who ingested excessive amounts (2-4 times the prescribed dose) of dapsone for hypopigmented macules and who developed, subacutely, progressive motor neuropathy a few months later. Pathologic studies on a biopsied motor nerve confirmed the electrophysiologic conclusion of distal motor axonopathy. All made a rapid recovery in a few months after dapsone was stopped, although electrical abnormalities persisted. One patient was a rapid acetylator of isoniazid.
}, year = {1987}, journal = {International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association}, volume = {55}, pages = {23-9}, month = {1987 Mar}, issn = {0148-916X}, language = {eng}, }