@article{10386,
  keywords = {Dapsone, Enzyme-Linked Immunosorbent Assay, Hemagglutination Tests, Humans, leprosy, Patient Compliance, Sensitivity and Specificity, Statistics as Topic},
  author = {Nagelkerke N J and Fidler V and Buwalda M},
  title = {Instrumental variables in the evaluation of diagnostic test procedures when the true disease state is unknown.},
  abstract = {<p>We explore the estimation of sensitivity and specificity of diagnostic tests when the true disease state is unknown. Instrumental variables which subdivide the patient population are used. A logistic model, relating these instrumental variables to the (unknown) true disease state is proposed. It is shown that this procedure allows the goodness-of-fit to the resulting model to be tested.</p>},
  year = {1988},
  journal = {Statistics in medicine},
  volume = {7},
  pages = {739-44},
  month = {1988 Jul},
  issn = {0277-6715},
  doi = {10.1002/sim.4780070703},
  language = {eng},
}