@article{10380,
  keywords = {Antigens, Bacterial, Humans, leprosy, Lymph Nodes, Lymphocyte Activation, Mycobacterium leprae, T-Lymphocytes, Tuberculin},
  author = {Desai S D and Birdi T J and Antia N H},
  title = {Presence of Mycobacterium leprae-reactive lymphocytes in lymph nodes of lepromatous leprosy patients.},
  abstract = {<p>A critical problem in leprosy is the relative deficiency of antigen-specific T cell-mediated immunity. We were successful in detecting a significant response to viable M. leprae in mononuclear cells isolated from the lymph nodes of lepromatous leprosy patients in contrast to the apparent M. leprae-specific energy seen in the peripheral blood. This observation suggests that antigen-reactive lymphocytes are generated in the lymph nodes of lepromatous patients but the inability to detect them in the circulation may be due either to a different processing and presentation of mycobacterial antigens within the peripheral blood and lymph node compartments or to a selective sequestration of lymphocytes within the lymph node.</p>},
  year = {1988},
  journal = {Scandinavian journal of immunology},
  volume = {28},
  pages = {211-6},
  month = {1988 Aug},
  issn = {0300-9475},
  doi = {10.1111/j.1365-3083.1988.tb02433.x},
  language = {eng},
}