@article{103490,
  keywords = {Glomerulonephritis, Infection, Mycobacterium avium},
  author = {Visch R and van Laarhoven A and Smits L and van Midden D and van de Logt A},
  title = {IgA Dominant Infection-Related Glomerulonephritis due to Mycobacterium avium: A Case Report},
  abstract = {<p>Immunoglobulin A-dominant infection-related glomerulonephritis (IgA-DIRGN) is a rare variant of acute postinfectious glomerulonephritis (GN), typically seen in elderly individuals with comorbidities. IgA-DIRGN is characterized by diffuse endocapillary proliferation and the formation of mesangial deposits of IgA and C3, leading to inflammation and subsequently resulting in acute kidney injury, proteinuria, hematuria, and hypocomplementemia. In this report, we describe an immunocompromised 68-year-old male who developed acute kidney injury, nephrotic-range proteinuria, and microscopic hematuria following a splenic&nbsp;<em>Mycobacterium avium</em>&nbsp;abscess. Kidney biopsy revealed endocapillary proliferative GN with IgA and C3-dominant granular deposits, consistent with IgA-DIRGN. Progression of renal dysfunction during antimycobacterial therapy prompted the use of glucocorticoids one month after the initial presentation and eventually a splenectomy one month later, followed by renal recovery. To our knowledge, this is the first case to report the association between a non-tuberculous mycobacterial infection and IgA-DIRGN, emphasizing the importance of source control and illustrating the usefulness of steroids in this patient.</p>
},
  year = {2026},
  journal = {Kidney Medicine},
  pages = {1 - 23},
  month = {04/2026},
  publisher = {Elsevier BV},
  issn = {2590-0595},
  url = {https://www.sciencedirect.com/science/article/pii/S2590059526001457/pdfft?md5=7dbcf844495d27f840d88e50cde48121&pid=1-s2.0-S2590059526001457-main.pdf},
  doi = {10.1016/j.xkme.2026.101383},
  language = {ENG},
}