@proceedings{103435,
  keywords = {Pterodon pubescens Extract, LDT-PPH, Neuropathic ulcer, Healing},
  author = {Menezes CN and Silva MG and Romeiro LAS and Santos ND and Damazo AS},
  title = {Topical Use of Pterodon pubescens Extract (LDT-PPH) in Healing of Neuropathic Ulcer in Leprosy: Case Report},
  abstract = {<p><strong>Introduction:</strong>&nbsp;</p>

<p>Hansen’s disease remains a public health challenge associated with neuropathic ulcers that are difficult to heal. Given the limitations of conventional treatment, therapies based on natural products have gained attention.&nbsp;Pterodon pubescens&nbsp;(white sucupira), a Cerrado species with reported anti-inflammatory and wound-healing properties, has not been clinically tested for leprosy ulcers. The aim of this study was to assess the healing potential of the hexane extract of&nbsp;P. pubescens&nbsp;(LDT-PPH) in leprosy-associated ulcers.&nbsp;</p>

<p><strong>Methodology:</strong></p>

<p>&nbsp;The patient was a 54-year-old female, smoker, with diabetes mellitus and hypertension. She was diagnosed with multibacillary leprosy in 2021, recurrence in 2024, grade II disability, and claw hand; underwent amputation of the third right finger; and was diagnosed with type II leprosy reaction in 2025 under treatment with thalidomide. She reported a chronic neuropathic ulcer on the second and third right fingers. Treatment consisted of daily dressings with 1% LDT-PPH in Dersani® for 56 days. Healing was monitored through photographs and the TIMERS framework (Tissue, Infection, Moisture, Edge, Regeneration, Social). This study was approved by the Research Ethics Committee under opinion number 7.675.9042025.&nbsp;</p>

<p><strong>Results:</strong>&nbsp;</p>

<p>Initially, the lesion measured 1.5 × 1.2 cm with mixed tissue (slough and granulation), mild inflammation, moderate exudate, and thickened edges (TIMERS score: 5). By the second evaluation, viable granulation tissue, adequate moisture, and active wound edges were observed (score: 10). At the end of treatment, the ulcer exhibited predominant scar tissue, active epithelialization, no infection, and controlled moisture (score: 11), demonstrating significant improvement.&nbsp;</p>

<p><strong>Conclusions:</strong></p>

<p>&nbsp;Topical application of LDT-PPH promoted healing of a neuropathic ulcer in Hansen’s disease, highlighting phytotherapy as an innovative, sustainable, and low-cost option for managing complex wounds.</p>
},
  year = {2026},
  journal = {The 6th International Congress on Health Innovation&amp;mdash;INOVATEC 2025},
  volume = {137},
  pages = {118},
  month = {03/2026},
  publisher = {MDPI},
  url = {https://www.mdpi.com/2504-3900/137/1/118/pdf},
  doi = {10.3390/proceedings2026137118},
  language = {ENG},
}