@article{102711,
  keywords = {high density lipoprotein, Interferon-gamma, Leprosy},
  author = {Hassan AR and El Sary AY and Mohamed SH and Hosnay R and Mohamad NE},
  title = {High-density lipoprotein levels and its correlation with Interferon-gamma levels in leprosy patients},
  abstract = {<p><strong>Background</strong></p>

<p>Mycobacterium lepra infection causes leprosy. Primarily affecting the skin and peripheral nerves, it is a persistent viral illness. Peripheral nerve damage can cause severe impairment and disability. The type of lipoproteins known as high-density lipoproteins (HDL) is distinguished by its capacity to return cholesterol from peripheral tissues to the liver. Their anti-inflammatory and antioxidant properties play a major part in their ability to prevent diseases. A pleiotropic molecule, interferon-gamma (IFN-γ) has mechanisms that are linked to antiproliferative, pro-apoptotic, and anticancer effects. Due to its ability to maintain both CD4+ and CD8+ cell activity and regulate a variety of protective functions, this effector cytokine is frequently regarded as a significant effector of immunity.</p>

<p><strong>Aim</strong></p>

<p>The current study aimed to evaluate HDL levels in sera of leprotic patients and assess its correlation with IFN-γ levels. Patients and methods This study included 31 leprotic patients and 30 healthy subjects as a control. Serum HDL is estimated by enzymatic methods using spectrophotometric assay kits while serum IFN-γ is estimated using commercially available enzyme-linked immunosorbent assay (ELISA).</p>

<p><strong>Results</strong></p>

<p>There was no statistically significant difference between the two studied groups regarding HDL. There was a higher statistically significant difference between the two studied groups regarding IFN-γ with higher levels in the cases group. There was no significant correlation between both HDL and IFN-γ and age and duration.</p>

<p><strong>Conclusion</strong></p>

<p>There is no correlation between serum levels of HDL and levels of IFN-γ in leprosy patients.</p>
},
  year = {2025},
  journal = {Egyptian Journal of Dermatology and Venereology},
  volume = {45},
  pages = {293-300},
  publisher = {Ovid Technologies (Wolters Kluwer Health)},
  issn = {1110-6530},
  url = {https://journals.lww.com/ejdv/_layouts/15/oaks.journals/downloadpdf.aspx?trckng_src_pg=ArticleViewer&an=01745968-202509000-00008},
  doi = {10.4103/ejdv.ejdv_63_24},
  language = {ENG},
}