@article{102284,
  keywords = {Lazarine leprosy, Ulcer leprosy, Non-trophic ulcer, non-neuropathic ulcer},
  author = {Bains A and Bhatia D and Mandiya S and Bhardwaj A and Singh S and Budania A and Patra S and Bandhala Rajan M},
  title = {A descriptive study of non-neuropathic ulcers in leprosy: a retrospective study in a tertiary hospital in India},
  abstract = {<p><strong>Background</strong></p>

<p>Cutaneous ulcers sometimes cause diagnostic confusion, whether they are due to disease, reactions or neuropathy. The present study aims to study the non-neuropathic cutaneous ulcers in leprosy.</p>

<p><strong>Methods</strong></p>

<p>Retrospective data from 2015 to 2023 were analyzed. Details were recorded in a pre-designed proforma.</p>

<p><strong>Results</strong></p>

<p>A total of 21 cases with non-neuropathic ulcers were recruited. The mean age was 46 years with a male predominance: 17 (81%). Most of the patients had lepromatous leprosy (LL) 13 (62%). A majority, 18 (86%) suffered from disability. The most common sites of ulceration were the arms and legs: 17 (81%). The most common presentation was crusted nodular-plaque lesions in 12 (56%) patients, followed by erosions over plaques in 4 (19%), ulcers with sloping margins in 2 (10%), punched out ulcers, ulceration in an annular configuration and jagged ulcers in 1 (5%) patient each. ENL was the most common cause of non-neuropathic cutaneous ulceration, clinically suspected in 17 patients (81%) and proven on histopathology in 14 (67%) patients. Chronic and recurrent ENL constituted (8/17 patients, 47%) almost half of the ENL cases. Spontaneous ulceration without any evidence of reaction was noted in 4 patients, BT leprosy in 1 (5%) patient and BL leprosy in 3 (14%) patients.</p>

<p><strong>Conclusion</strong></p>

<p>Most of the patients with non-neuropathic ulcers had LL or BL leprosy, and nearly eighty-five percent suffered from disability. ENL was the most common cause of non-neuropathic cutaneous ulceration, out of which chronic and recurrent ENL constituted half of cases. Spontaneous ulceration without any evidence of reaction was noted in only a few patients.</p>
},
  year = {2025},
  journal = {Leprosy Review},
  volume = {96},
  pages = {1-12},
  publisher = {Lepra},
  issn = {2162-8807},
  url = {https://leprosyreview.org/article/96/2/20-24111},
  doi = {10.47276/lr.96.2.2024111},
  language = {eng},
}